Research status and progress of endoplasmic reticulum stress in scleral remodeling
10.3760/cma.j.cn511434-20221201-00634
- VernacularTitle:内质网应激在巩膜重塑中的研究现状及进展
- Author:
Zhao LIU
1
;
Bing XIE
;
Shanjun CAI
Author Information
1. 遵义医科大学附属医院眼科 贵州省眼科医院 国家眼病临床研究中心贵州省分中心 贵州省眼疾病特色重点实验室, 遵义 563003
- Keywords:
Endoplasmic reticulum stress;
Sclera remodeling;
Myopia;
Inositol-requiring protein 1;
Protein kinase RNA-like endoplasmic reticulum kinase;
Activating tra
- From:
Chinese Journal of Ocular Fundus Diseases
2023;39(10):873-878
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of myopia is closely related to scleral remodeling. Therefore, in order to effectively prevent and cure myopia, it is very important to clarify the mechanism of scleral remodeling. In recent years, Chinese scholars have found that endoplasmic reticulum stress can regulate the expression of apoptotic proteins through the inositol demand protein-1/X box binding protein-1 pathway in the unfolded protein response, thus it is involved in regulating the state of scleral fibroblasts under hypoxia and regulating the occurrence and development of scleral remodeling. At the same time, some studies have found that inhibiting and knocking out protein kinase RNA-like endoplasmic reticulum kinase and activated transcription factor 6 in endoplasmic reticulum stress can effectively inhibit the growth of ocular axis. This proves that endoplasmic reticulum stress plays an important role in the occurrence and development of scleral remodeling. However, the comprehensive analysis of endoplasmic reticulum stress and scleral remodeling has not been reported at home and abroad. In-depth analysis of the relationship between endoplasmic reticulum and scleral remodeling is of great significance for the follow-up analysis and study of the mechanism of scleral remodeling.
