Research progress of ferroptosis involved in the pathogenesis of diabetic retinopathy
10.3760/cma.j.cn511434-20220801-00430
- VernacularTitle:铁死亡参与糖尿病视网膜病变发病机制的研究进展
- Author:
Shaojie REN
1
;
Manhong XU
;
Xiaorong LI
Author Information
1. 天津医科大学眼科医院、眼视光学院、眼科研究所 国家眼耳鼻喉疾病临床医学研究中心天津市分中心 天津市视网膜功能与疾病重点实验室, 天津 300384
- Keywords:
Diabetic retinopathy;
Ferroptosis;
Iron overload;
Oxidative stress injury;
Reactive oxygen species;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2023;39(10):868-872
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) constitutes a major retinal vascular disorder leading to blindness in adults. Current therapeutic approaches for DR exhibit certain degrees of efficacy but are constrained by a spectrum of limitations. Hence, there is a pressing need to deeply investigate the underlying pathogenesis of DR and explore novel therapeutic targets. Ferroptosis, a distinctive form of programmed cell death, has emerged as a pertinent phenomenon in recent years. Notably, ferroptosis has been implicated in the progression of DR through mechanisms involving the induction of retinal oxidative stress, provocation of anomalous retinal vascular alterations, exacerbation of retinal neural damage, and elicitation of immune dysregulation. Thus, elucidating the mechanistic role of ferroptosis in DR holds the potential to establish a robust foundational rationale. This could potentially facilitate the clinical translation of ferroptosis inhibitors as promising agents for the prevention and treatment of DR, thereby forging novel avenues in the landscape of DR management.