Fatal PTLD Accompanied by Rapid Lymphocyte Proliferation in the Early Phase of Allogeneic HSCT.
10.3904/kjm.2015.89.2.243
- Author:
Jung Yeon LEE
1
;
Gyuri KIM
;
Eunyoung LEE
;
Se Hee PARK
;
Jin Seok KIM
;
June Won CHEONG
;
Yoo Hong MIN
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. minbrmmd@yuhs.ac
- Publication Type:Case Report
- Keywords:
Epstein-Barr virus infections;
Transplantation;
Lymphoproliferative disorder
- MeSH:
Adult;
Bone Marrow;
Epstein-Barr Virus Infections;
Female;
Hematopoietic Stem Cell Transplantation;
Herpesvirus 4, Human;
Humans;
Lymphocytes*;
Lymphocytosis;
Lymphoproliferative Disorders;
Organ Transplantation;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Transplantation;
Transplants
- From:Korean Journal of Medicine
2015;89(2):243-248
- CountryRepublic of Korea
- Language:English
-
Abstract:
Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of clinically and morphologically heterogeneous lymphoid proliferations of various clonal compositions that are observed after hematopoietic stem cell transplantation (HSCT) or solid organ transplantation. The majority of PTLD cases are associated with Epstein-Barr virus (EBV) infection, while overt peripheral blood (PB) or bone marrow (BM) involvement in PTLD is uncommon in early lesions. We report a 38-year-old woman with EBV-related PTLD, with BM and PB involvement, who presented with peripheral lymphocytosis as an early lesion 1 month after haploidentical HSCT for Philadelphia chromosome-positive acute lymphoblastic leukemia was performed during first complete remission. Although PB or BM involvement of PTLD after HSCT is uncommon in early lesions, peripheral lymphocytosis can be an initial presenting manifestation of PTLD, as in this case.
