Interaction between Schwann cells and macrophages during regeneration process after peripheral nerve injury
10.3760/cma.j.cn441206-20230913-00038
- VernacularTitle:周围神经损伤后再生过程中许旺细胞与巨噬细胞的交互作用
- Author:
Yilin HUO
1
;
Haodong LIN
Author Information
1. 上海交通大学医学院附属第一人民医院创伤中心，上海 201600
- Keywords:
Peripheral nerve injury;
Nerve regeneration;
Schwann cells;
Macrophages;
Interaction
- From:
Chinese Journal of Microsurgery
2024;47(1):104-109
- CountryChina
- Language:Chinese
-
Abstract:
As the important components of peripheral nerve tissue, Schwann cells and macrophages interact with each other throughout the whole process of nerve regeneration. They play a key role in Wallerian degeneration, myelin clearance, axonal regeneration and target organ reinnervation in promotion of the repair of a peripheral nerve. In order to improve the simple strategy in treatment of peripheral nerve injury (PNI), great attention about the significance interaction mechanism between Schwann cells and macrophages in the process of nerve regeneration should be paid, as well as the continuous improvement in researches on the repair mechanism of a PNI. Trauma Centre, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine summarises the interaction mechanism of Schwann cells and macrophages in the regeneration of PNI through literature reviews, from 2015 to 2023, on the mechanisms of Schwann cells and macrophages in PNI repair, hence to draw new ideas in the research and clinical treatment of PNI.
