Comparison of effects of streptavidin and dimethylsilicone oil on the detection rate of microscopic lesions under gastroscopy
10.3760/cma.j.cn321463-20230328-00568
- VernacularTitle:链霉蛋白酶与二甲硅油对胃镜检查微小病变检出率影响的比较
- Author:
Haibin ZHANG
1
;
Qinwei XU
;
Tao CHEN
;
Kang FANG
;
Li SHEN
;
Yanli NI
;
Meidong XU
Author Information
1. 同济大学附属东方医院内镜中心，上海 200120
- Keywords:
Pronase;
Gastroscopy;
Visual fields
- From:
Chinese Journal of Digestive Endoscopy
2023;40(11):921-924
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of streptavidin and dimethylsilicone oil on the detection rate of microscopic lesions under gastroscopy, a total of 353 patients who underwent painless gastroscopy were categorized into the experimental group (given streptavidin combined with sodium bicarbonate, n=176) and the control group (given dimethylsilicone oil combined with sodium bicarbonate, n=177). Clinical indexes such as visual field clarity, examination duration, number of rinses, detection rate of micro lesions, early cancer detection rate and incidence of adverse reactions were recorded in the gastroscopy examination of the two groups. The experimental and control groups were compared in terms of visual field clarity (1.84±0.51 points VS 2.15±0.48 points, t=-5.900), fundus mucus properties (1.04±0.43 points VS 1.46±0.76 points, t=-6.347) and number of rinses (0.76±0.66 times VS 1.18±0.72 times, t=-5.628) with significant differences ( P<0.001). The examination time in the experimental group was slightly higher than that in the control group (10.01±4.40 min VS 8.98±4.22 min, t=2.239, P=0.026). The detection rate of microscopic lesions was significantly higher in the experimental group than that in the control group [97.73%(172/176) VS 91.53%(162/177), χ2=6.665, P=0.010]. There was no significant difference in the detection rate of inflammatory hyperplasia, polyps, precancerous lesions or cancer between the experimental group and the control group ( P>0.05). There was no preoperative drinking discomfort in either group, and 4 cases of intraoperative choking occurred in each of the experimental and the control group with no significant difference ( P>0.999). No postoperative adverse reaction occurred in either group. Taking streptavidin before operation could significantly improve visual field clarity and the detection rate of microscopic lesions, which helps to detect early lesions in stomach.
