Research progress in functional polarization of tumor-associated macrophages and targeting strategies
10.3760/cma.j.cn112309-20231101-00118
- VernacularTitle:肿瘤相关巨噬细胞功能极化与靶向策略研究进展
- Author:
Bei WANG
1
;
Wenbo LI
;
Xuran ZHANG
;
Weihong REN
Author Information
1. 河南中医药大学第一临床医学院，郑州 450046
- Keywords:
Tumor microenvironment;
Tumor-associated macrophage;
Metabolic reprogramming;
Epigenetic reprogramming;
Functional polarization
- From:
Chinese Journal of Microbiology and Immunology
2024;44(3):265-273
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages (TAMs) are the predominant immune cells in the tumor microenvironment (TME). They have been shown to play an important immunosuppressive role in the development of TME and promote tumor immune escape, growth and metastasis. It is a current research hotspot to regulate the functional polarization of TAMs through trained immunity (metabolic reprogramming, epigenetic remodeling) to affect the occurrence and development of tumors. Therefore, in-depth research in this field not only presents a more comprehensive perspective on the pathogenesis of immune-mediated diseases, but also can provide new strategies for clinical anti-tumor immunotherapy. This paper outlines the origin of TAMs and the phenotypes and mechanisms of TAMs polarization, discusses the mechanisms by which metabolic reprogramming and epigenetic remodeling regulate TAMs, summarizes the regulation of TAMs activation and polarization by them, and provides an overview of the progress in TAMs at the current stage of clinical practice, hoping to provide reference for the development of new immunoprevention and treatment strategies.
