Outbreak and clinical features of respiratory syncytial virus in Chengde from 2022 to 2023
10.3760/cma.j.cn112309-20231228-00193
- VernacularTitle:2022—2023年承德市呼吸道合胞病毒的暴发流行及其临床特征研究
- Author:
Qiange MA
1
;
Shuchang GAO
;
Xinyue GUO
;
Mengyao YAN
;
Zuxi HU
;
Guangcheng XIE
;
Tao LI
Author Information
1. 承德医学院第二临床学院儿科，承德 067000
- Keywords:
Respiratory syncytial virus;
Epidemiological characteristics;
Clinical features;
Children
- From:
Chinese Journal of Microbiology and Immunology
2024;44(2):155-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the prevalence and clinical features of respiratory syncytial virus (RSV) in Chengde city.Methods:From August 2022 to June 2023, throat swabs and clinical data of 478 hospitalized children with respiratory tract infection in the Chengde Central Hospital were collected. Real-time quantitative PCR was used to detect the molecular epidemiology of RSV-A and RSV-B subtypes and analyze the clinical features of patients with RSV infection.Results:Among the hospitalized children, 67.57% (323/478) tested positive for RSV. The outbreak of RSV infection was caused by RSV-A subtype. The peaks of RSV-A infection occurred from November to December, 2022 and May to June, 2023. There were 86.07% (278/323) of the RSV-A-positive cases had mixed infection with other pathogens, primarily bacterial pathogens with Streptococcus pneumoniae being the most common, followed by Klebsiella pneumoniae. Influenza virus A was the most common viral pathogens causing mixed infection. The level of lactate dehydrogenase was higher in the patients with single RSV-A infection than in those with mixed infection ( Z=2.396, P=0.017), and higher than the normal upper limit. Compared with the single infection group, the mixed infection group had higher white blood cell count ( Z=2.417, P=0.016), neutrophil ratio ( Z=3.218, P=0.001), C-reactive protein level ( Z=1.998, P=0.046) and creatinine level ( Z=2.107, P=0.035), and lower lymphocyte ratio ( Z=3.205, P=0.001), but they were all within the normal range. There were no significant differences in the clinical features between RSV-A-positive patients co-infected with bacteria or other viruses (all P>0.05). Conclusions:RSV-A is the leading cause of respiratory tract infection in children in Chengde from 2022 to 2023, and often co-detected with bacteria. The mixed infection with other respiratory pathogens is related to the clinical features of patients with RSV-A infection.
