Application of microfluidics in anti-infectious immunity
10.3760/cma.j.cn112309-20231130-00158
- VernacularTitle:微流控技术在抗感染免疫研究中的应用
- Author:
Boyang LIU
1
;
Linjing ZHU
;
Fang FANG
;
Yan QI
;
Xueling CUI
Author Information
1. 吉林大学基础医学院细胞生物学与医学遗传学系，吉林省神经免疫与临床免疫重点实验室，长春 130021
- Keywords:
Microfluidic chip;
Infection immunity;
Cell migration;
Bacteria;
Quick assay
- From:
Chinese Journal of Microbiology and Immunology
2024;44(1):34-38
- CountryChina
- Language:Chinese
-
Abstract:
The immune response against infection is a multifaceted process encompassing the activation and migration of diverse immune cells, as well as the clearance of pathogens. The behaviors of immune cells and the identification of pathogens play pivotal roles as indicators for disease diagnosis and prediction. In recent years, the utilization of microfluidic chip technology has gained substantial attention within the areas of biology, pharmacology, and clinical research and diagnosis. This is primarily attributed to the numerous advantages it offers, including miniaturization, enhanced throughput, heightened sensitivity, expedited analysis, and reduced sample consumption. As a result, microfluidic technology has facilitated the development and utilization of immune cell behavioral assays, bacterial growth studies, and drug-screening assays. This paper is to review the application of microfluidic technology in the field of anti-infection immunity research, focusing on the analysis of migratory behavior of innate immune cells, deformation of their nuclei, and rapid identification of pathogenic bacteria and viruses. The primary objective of this review is to advance the application of microfluidic technology in research on both anti-infection immunity and clinical diagnosis.
