Progress in autophagy regulated by hepatitis B virus infection
10.3760/cma.j.cn112309-20230701-00196
- VernacularTitle:乙型肝炎病毒感染调控细胞自噬的研究进展
- Author:
Zhen WEI
1
;
Sihui LI
;
Chen LI
;
Haihuan TANG
;
Yong LIN
Author Information
1. 重庆医科大学感染性疾病分子生物学教育部重点实验室，重庆 400016
- Keywords:
Hepatitis B virus;
Autophagy;
Autophagic degradation;
Innate immunity;
Adaptive immunity
- From:
Chinese Journal of Microbiology and Immunology
2023;43(11):874-880
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection can cause a series of severe liver diseases such as chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma, remaining one of most serious worldwide public health problems. Autophagy is a conserved lysosome-dependent degradation pathway in eukaryotic cells and plays a critical role in host innate immune response. Multiple processes in the life cycle of HBV, including viral replication, maturation and secretion, are closely related to autophagy. Autophagy can regulate the assemble, envelopment and secretion of HBV in human hepatocytes and participate in innate and adaptive immune responses to clear HBV. HBV induces strong autophagy in human hepatocytes and escapes autophagic degradation through certain mechanisms. This review summarized the progress in autophagy and autophagic degradation regulated by HBV infection, hoping to provide a theoretical reference for further understanding the mechanism of autophagy regulated by HBV infection and developing novel strategies for anti-HBV therapy.
