Progress in influenza virus polymerase basic protein 1-related host factors
10.3760/cma.j.cn112309-20230828-00054
- VernacularTitle:流感病毒聚合酶碱性蛋白1相关宿主因子研究进展
- Author:
Haoru LIU
1
;
Shengyu WANG
;
Xin SUN
;
Hong SONG
Author Information
1. 遵义医科大学基础医学院微生物学教研室，遵义 563000
- Keywords:
Influenza virus;
Host factors;
Polymerase basic protein 1
- From:
Chinese Journal of Microbiology and Immunology
2023;43(11):860-867
- CountryChina
- Language:Chinese
-
Abstract:
Influenza viruses are a serious threat to human health and have a major impact on social development, making them a public health and safety hazard worldwide. Therefore, understanding the life cycle of influenza viruses can provide strategies for fighting viral infections. After influenza virus infection, host cells will defend themselves against the virus by activating the innate immune system. There is a close relationship between the virus and host factors, as host factors are required at each stage of the influenza virus life cycle and have different effects on virral proliferation. Polymerase basic protein 1 (PB1), an RNA polymerase subunit, is a key viral protein in influenza virus replication and transcription. This review summarized how different host factors interact with PB1 to regulate the replication, transmission and pathogenicity of influenza viruses, providing new ideas for the development of antiviral drugs.
