Progress in antiviral strategies targeting influenza virus hemagglutinin
10.3760/cma.j.cn112309-20230829-00056
- VernacularTitle:以流感病毒血凝素为靶标的抗病毒防治策略研究进展
- Author:
Ming CAI
1
;
Xuedan LI
;
Liang SHAO
;
Feixia PENG
;
Zhegang ZHANG
;
Bo LIU
;
Xuanxuan NIAN
;
Jiayou ZHANG
;
Hui CAO
;
Xiaoming YANG
Author Information
1. 武汉生物制品研究所有限责任公司病毒性疫苗研究二室，武汉 430207
- Keywords:
Influenza virus;
Hemagglutinin;
Influenza vaccine;
Broad-spectrum neutralizing antibody;
Antiviral drug
- From:
Chinese Journal of Microbiology and Immunology
2023;43(11):850-859
- CountryChina
- Language:Chinese
-
Abstract:
Influenza is a worldwide infectious disease caused by influenza virus. It has posed great challenges on public health and social stability since 1918. At present, vaccination is the most effective way to prevent and control influenza epidemics. Broad-spectrum antiviral drugs and neutralizing antibodies against influenza virus have been widely studied in recent years. Hemagglutinin (HA), which is on the surface of influenza virus, plays an important role in the stage of viral invasion into host cells. It is the main effective antigenic component of current influenza vaccines, as well as the main target of broad-spectrum neutralizing antibodies and broad-spectrum antiviral drugs. This review summarized the progress in the development of novel influenza vaccines, neutralizing antibodies, and antiviral drugs based on influenza virus HA, as well as other prevention and control measures, hoping to present new ideas for future influenza prevention and control.
