Progress in universal influenza vaccines targeting hemagglutinin and other conserved epitopes of influenza A virus
10.3760/cma.j.cn112309-20230523-00143
- VernacularTitle:基于甲型流感病毒血凝素及联用其他保守表位的通用流感疫苗研究进展
- Author:
Yuying DENG
1
;
Shuzhen LIU
;
Lanshu LI
;
Chenyan ZHAO
;
Weijin HUANG
Author Information
1. 中国食品药品检定研究院生物制品检定所艾滋病性病病毒疫苗室，国家卫生健康委员会生物技术产品检定方法与标准化重点实验室，北京 102629
- Keywords:
Influenza A viruses;
Hemagglutinin;
Conservative epitope;
Universal influenza vaccine
- From:
Chinese Journal of Microbiology and Immunology
2023;43(11):813-822
- CountryChina
- Language:Chinese
-
Abstract:
Influenza viruses are responsible for a large number of infections and deaths annually, posing a serious threat to public health. Vaccination is the most effective measure to prevent influenza virus infection. However, current seasonal influenza vaccines only protect against closely matched circulating strains. Even with extensive surveillance and annual reformulation, yearly updated vaccines are still a step behind the fast-evolving viruses, often resulting in poor matches or less effective vaccines. Due to the relatively complex evolution of influenza A viruses, it is a new idea and a new means to prevent influenza epidemics by using a series of innovative technologies to develop universal influenza vaccines that can provide extensive and long-lasting protection against influenza viruses. This review summarized the latest progress in the development of universal vaccines targeting HA in the past three years, including design methods for universal vaccines targeting HA, HA stem and other conserved epitopes, compared the advantages and disadvantages of different technologies, explored the impact of immunization programs and strategies, and discussed the potential challenges to be overcome, hoping to provide reference for the successful development of universal vaccines.
