A survey of tetanus antibody levels in 7 519 healthy people in Henan Province
10.3760/cma.j.cn112309-20230523-00142
- VernacularTitle:河南省7 519名健康人群破伤风抗体水平调查
- Author:
Qian LIU
1
;
Yonghao GUO
;
Jiangnan KONG
;
Daxing FENG
;
Yanyang ZHANG
Author Information
1. 河南省疾病预防控制中心免疫预防医学重点实验室，郑州 450016
- Keywords:
Tetanus;
Antibody level;
Boost immunization
- From:
Chinese Journal of Microbiology and Immunology
2023;43(9):704-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze tetanus antibody levels in healthy people in Henan Province and to provide reference data for the adjustment of tetanus vaccine immunization strategy.Methods:A total of 7 519 healthy people were selected using stratified sampling in Henan Province from 2020 to 2021. Serum samples were collected and tested for anti-tetanus toxoid IgG antibody (anti-TT) by ELISA. The positive rate (≥0.01 IU/ml), protection rate (≥0.1 IU/ml) and mean concentration (MC) of anti-TT were analyzed.Results:The overall positive rate, protection rate and MC of anti-TT among the 7 519 subjects were 70.33% (5 288/7 519), 37.07% (2 787/7 519) and 0.035 IU/ml, respectively. Both basic and booster tetanus vaccines were effective. The positive rate, protective rate and MC of anti-TT decreased from 99.63% (272/273), 82.05% (224/273) and 0.215 IU/ml in 6-year-olds to 64.22% (262/408), 21.57% (88/408) and 0.023 IU/ml in 16- to 19-year-olds, and further decreased to 40.97% (1 302/3 178), 5.48% (174/3 178) and 0.007 IU/ml in people ≥20 years old.Conclusions:The level of tetanus antibody decreased with age in healthy people in Henan Province. It was suggested that the sixth dose of tetanus vaccine should to be given at 16-20 years old.
