The effect of transcranial direct current stimulation on the functional connectivity of language-related brain areas in patients with post-infarction picture-naming dysfunction: a resting state functional magnetic resonance study
10.3760/cma.j.issn.0254-1424.2024.01.007
- VernacularTitle:基于静息态fMRI技术观察经颅直流电刺激对脑梗死后图命名障碍患者语言相关脑区功能连接的影响
- Author:
Yancheng SONG
1
;
Liqing KANG
;
Fenghai LIU
;
Xiaoxuan WANG
;
Yanlong YANG
;
Min SUN
;
Lu SHAN
;
Zhao MENG
Author Information
1. 沧州市中心医院磁共振成像科
- Keywords:
re-fMRI;
tDCS;
Infarction;
Aphasia;
Functional connectivity
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2024;46(1):32-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of transcranial direct current stimulation (tDCS) on functional connectivity (FC) in language-related brain regions of patients with picture-naming dysfunction after cerebral infarction by using resting state functional magnetic resonance imaging(rs-fMRI).Methods:Twenty-eight patients with post-infarction picture-naming dysfunction were divided into an acute stage group( n=16) and a recovery stage group( n=12) according to the course of the disease, and 18 middle-aged and elderly volunteers were recruited as the normal control group.The anodic tDCS was applied on the posterior perisylvian region(PPR) of the left sylvian of the patients, 5 days a week for 2 weeks.Before and after the 2 weeks′ treatment, the rs-fMRI and Psycholinguistic Assessment of Chinese Aphasia (PACA)-picture-naming subscale were performed, and FC changes in language-related brain areas were observed. Results:After treatment, the PACA scores of patients in both acute and recovery stage groups were significantly improved after treatment( P<0.05). Compared with normal subjects, FC in multiple brain regions and particularly the Wernicke area was reduced in both cerebral hemispheres among the patient group. It was more severe in the dominant hemisphere.After the tDCS treatment, FC in both frontotemporal lobes and in the Wernicke area was significantly enhanced in both the acute and recovery groups. Further comparison showed that in the acute group FC in both temporo-occipital lobes was significantly enhanced after treatment. In the recovery group, the enhanced FC in the left temporal lobe before the treatment was significantly reduced after treatment. Conclusion:The fMRI technique can evaluate changes in brain connectivity in aphasia patients with picture-naming dysfunction after cerebral infarction accurately and non-invasively.tDCS may improve picture-naming function of stroke patients by enhancing the FC in bilateral language-related brain areas(concentrated in frontotemporal lobes) and Wernicke area.
