Research progress in the pathogenesis of long-term chronic kidney disease associated with preterm birth and low birth weight
10.3760/cma.j.cn113903-20230810-00100
- VernacularTitle:早产/低出生体重相关远期慢性肾脏病发病机制研究进展
- Author:
Fangrui DING
1
;
Jun ZHENG
Author Information
1. 天津市中心妇产科医院新生儿科，天津 300000
- Keywords:
Renal insufficiency, chronic;
Podocytes;
Infant, premature;
Infant, low birth weight
- From:
Chinese Journal of Perinatal Medicine
2024;27(3):253-257
- CountryChina
- Language:Chinese
-
Abstract:
With the development of neonatal intensive care, both the live birth rate and survival rate of preterm infants, especially in extremely preterm infants, have escalated. However, the long-term adverse prognosis of preterm infants became increasingly conspicuous. In the field of kidney disease, the existing clinical data have substantiated a higher susceptibility to chronic kidney disease (CKD) development during childhood or adulthood in preterm and low-birth-weight infants when compared with full-term infants. This suggests that preterm and/or low birth weight increases the risk for long-term CKD. Nonetheless, little attention has been paid to long-term CKD associated with preterm and/or low birth weight and the mechanism involved in this process is unknown. Current studies have suggested that reduced nephron and podocyte depletion are involved in this process, but detailed molecular mechanism remains inadequate. Therefore, this article reviews the research progress of long-term CKD correlated with preterm and/or low birth weight.
