Research progress on rodent models for white matter injury in premature infants
10.3760/cma.j.cn113903-20230720-00022
- VernacularTitle:早产儿脑白质损伤啮齿类动物模型研究进展
- Author:
Yueqi LI
1
;
Zhiwei ZHANG
;
Zhenlang LIN
;
Mingchu FANG
Author Information
1. 温州医科大学第二临床医学院，温州 325006
- Keywords:
Brain injuries;
White Matter;
Disease models, animal;
Infant, premature
- From:
Chinese Journal of Perinatal Medicine
2023;26(12):1045-1050
- CountryChina
- Language:Chinese
-
Abstract:
Animal models play a critical role in the research on the pathogenesis and treatment of white matter injury in premature infants. Rodent modeling is often used to mimic the pathological manifestations of white matter injury in premature human infants. Currently, the most used models include the common carotid artery occlusion combined with the hypoxia model, prenatal/postpartum infection model, chronic hypoxia model, hyperoxia exposure model, neuronal excitotoxicity model, transgenic model, etc. This article reviews the modeling methods, advantages, and disadvantages of the above models.
