Researches progress on pathogenesis of IgA nephropathy
10.3760/cma.j.cn441217-20230411-00418
- VernacularTitle:IgA肾病发病机制的研究进展
- Author:
Gangan WANG
1
;
Ke ZHENG
;
Xuemei LI
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院肾内科，北京 100730
- Keywords:
Glomerulonephritis, IgA;
Immunoglobulin A;
Antigen-antibody complex;
Galactose-deficient IgA1;
Multiple hit hypothesis;
Pathogenesis
- From:
Chinese Journal of Nephrology
2024;40(3):225-230
- CountryChina
- Language:Chinese
-
Abstract:
IgA nephropathy (IgAN) is currently the most common primary glomerulonephritis worldwide, with 20%-40% of patients progressing to end-stage renal disease within 20 years of diagnosis. At present, the pathogenesis of IgAN is not clear, and clinical treatment is mainly to control the progression, without specific treatment plan. A series of studies on galactose-deficient IgA1 (Gd-IgA1) suggest that the pathogenesis of IgAN involves multiple links. This review summarizes the research progress on the pathogenesis of IgAN, covering the structure characteristics of IgA1, Gd-IgA1 antibodies and Gd-IgA1 immune complexes in IgAN patients, the deposition of Gd-IgA1 immune complexes in the kidneys, kidney damage following the deposition of Gd-IgA1 immune complexes, the role of complement in IgAN, the genomics of IgAN, and mucosal immunity in IgAN, providing clues and insights for further research and clinical treatment.
