Advances of erythroferrone in iron metabolism and renal anemia
10.3760/cma.j.cn441217-20230428-00443
- VernacularTitle:Erythroferrone在铁代谢与肾性贫血中的研究进展
- Author:
Qiuyu XU
1
;
Gang CHEN
;
Xuemei LI
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内科，北京 100730
- Keywords:
Renal insufficiency, chronic;
Anemia;
Iron metabolism disorder;
Hypoxia inducible factor;
Hepcidin
- From:
Chinese Journal of Nephrology
2023;39(12):951-956
- CountryChina
- Language:Chinese
-
Abstract:
Erythroferrone is a newly discovered and important factor regulating iron homeostasis and mainly produced by erythroblasts. Erythroferrone responds to the increase of erythropoietin and regulates plasma iron level, along with the absorption and utilization of iron via hepcidin, which plays an important role in the pathophysiology of iron metabolism-related diseases. Erythropoietin deficiency and iron metabolism disturbance are prominent features of renal anemia complicated with chronic kidney disease. Accordingly, erythroferrone is corresponding to the pathogenesis, treatment and prognosis of renal anemia. The in-depth study contributes to the further understanding of the mechanism related to iron metabolism disorder, and erythroferrone is also expected to be used as a valuable biomarker in the detection of renal anemia and the evaluation of therapeutic response. The article systematically reviews the physiological function of erythroferrone and its research progress in iron metabolism and renal anemia.
