Role of gut microbiota in the pathogenesis and treatment of chronic kidney disease
10.3760/cma.j.cn441217-20221117-01134
- VernacularTitle:肠道菌群在慢性肾脏病进展和治疗中的作用
- Author:
Yangyang ZHANG
1
;
Jiayuan HUANG
;
Shan JIANG
;
Wanying KANG
;
Wenjing ZHAO
;
Zhihua ZHENG
Author Information
1. 中山大学附属第七医院肾脏病中心，深圳518107
- Keywords:
Renal insufficiency, chronic;
Gastrointestinal microbiome;
Uremia;
Fecal microbiota transplantation;
Microecologics
- From:
Chinese Journal of Nephrology
2023;39(9):722-728
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease (CKD) is a serious health problem worldwide, whereas there is still no efficient cure. The gut microbiota plays a crucial role in maintaining human health and disease resistance, and multiple studies have confirmed that the gut microbiota is closely related to the occurrence and development of CKD. Starting from the "gut-kidney axis" theory, this article provides a systematic review of the changes in gut microbiota composition and function in patients with CKD, such as a decrease in the abundance of butyrate-producing bacteria Roseburia and Faecalibacterium prausnitzii. Besides that, the article explores the mechanisms by which the gut microbiota affects CKD progression, such as inflammation and immunity, and also describes the application methods of using the gut microbiota as a therapeutic target for CKD, such as fecal microbiota transplantation, microecologics, and dietary therapy, in order to provide microbial- based targets for the clinical diagnosis and treatment of CKD.
