Syphilis-related membranous proliferative glomerulonephritis with fever, skin rash and generalized lymph node enlargement as the initial manifestations: a case report
10.3760/cma.j.cn441217-20230227-00235
- VernacularTitle:以发热、皮疹、全身淋巴结肿大为首发表现的梅毒相关膜增生性肾小球肾炎1例
- Author:
Bo CHEN
1
;
Ziyuan HUANG
;
Duo LI
;
Chaosheng CHEN
Author Information
1. 温州医科大学附属第一医院肾内科，温州 325000
- Keywords:
Syphilis;
Glomerulonephritis, membranoproliferative;
Lymph nodes;
Syphilitic nephropathy
- From:
Chinese Journal of Nephrology
2023;39(9):705-707
- CountryChina
- Language:Chinese
-
Abstract:
A case of syphilis-related membranous proliferative glomerulonephritis is reported, presenting with fever, rash, generalized lymphadenopathy, and peripheral hypocytosis as the initial symptoms. The patient was admitted to the hospital and underwent various examinations to rule out lymphoma and other diseases. Subsequently, the patient developed edema with proteinuria. The toluidine red unheated serum test (TRUST) was 1∶4 (+) and the treponema pallidum particle agglutination (TPPA) test was >1∶160 (+). The pathological results of renal biopsy revealed membranous proliferative glomerulonephritis. The diagnosis of the patient was considered syphilitic nephropathy. Treatment with penicillin resulted in improvement of the condition. The coexistence of syphilitic nephropathy and membranous proliferative glomerulonephritis is rare and should be given careful attention in clinical practice. Antisyphilitic treatment improves the prognosis.
