Quantity detection of substantia nigra hyperechogenicity based on digital analysis for diagnosing Parkinson′s disease
10.3760/cma.j.cn113694-20230824-00080
- VernacularTitle:黑质高回声数字化分析在帕金森病患者中的诊断价值
- Author:
Hongling GAO
1
;
Jiangting LI
;
Qingmei YANG
;
Cong ZHOU
;
Tailong ZHU
;
Xiao ZHOU
;
Anyu TAO
;
Zheng XUE
Author Information
1. 华中科技大学同济医学院附属同济医院神经内科，武汉430030
- Keywords:
Parkinson disease;
Ultrasonography, Doppler, transcranial;
Substantia nigra;
Diagnosis;
Quantitative analysis
- From:
Chinese Journal of Neurology
2024;57(2):149-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To apply digital analysis to quantify hyperechogenicity of substantia nigra, and explore its clinical value for diagnosis of Parkinson′s disease (PD).Methods:The cross-sectional study included 652 PD patients (PD group) and 99 healthy controls (healthy control group) from November 2017 to October 2020 in Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology. All subjects underwent transcranial sonography. The diagnostic accuracy of substantia nigra hyperechogenicity using digital analysis was compared with that in a manual measurement in PD. Furthermore, the receiver operating characteristic (ROC) curve analysis was applied to explore its diagnosis value in PD.Results:There were 482 subjects including 400 in the PD group and 82 in the healthy control group, whose quantified results of substantia nigra hyperechogenicity could be used for analysis. The ROC analysis showed that the area under the curve of the quantified larger substantia nigra hyperechoic region detection for diagnosing PD was 0.858 (95% CI 0.805-0.910), the sensitivity was 87.8%, and the specificity was 73.2%, consistent with that of doctors (area under the curve: 0.884). Further more, among these PD patients, there was no correlation between larger substantia nigra hyperechogenicity and age, age of onset, course of disease, non-motor symptoms, and motor symptoms (all P>0.05). Conclusions:Digital analysis was used to quantify the changes in substantia nigra hyperechogenicity in this seudy. The results showed that diagnostic accuracy for PD based on digital analysis was consistent with that of experienced clinicians.
