CD20 +T cells in multiple sclerosis
10.3760/cma.j.cn113694-20230909-00136
- VernacularTitle:CD20 +T淋巴细胞在多发性硬化中的作用及机制研究
- Author:
Longxing XUE
1
;
Hongbo LIU
Author Information
1. 郑州大学第一附属医院神经内科，郑州 450052
- Keywords:
Multiple sclerosis;
CD20 +T cells;
B cells;
T cells
- From:
Chinese Journal of Neurology
2024;57(1):92-97
- CountryChina
- Language:Chinese
-
Abstract:
CD20 is a classic marker expressed by B cells. However, recent studies have found that CD20 is also dimly expressed on a small subset of CD3 +T cells, and the CD20 +T cells play an important proinflammatory role in multiple sclerosis (MS). Anti-CD20 monoclonal antibodies selectively deplete CD20 +T cells and effectively suppress inflammatory disease activity. Although CD20 +T cells have received increasing attention, the understanding of these cells is currently still in its infancy. This article provides an overview of the current knowledge about advanced progress of CD20 +T cells as well as their roles in MS.
