A case of rhino-orbito-cerebral mucormycosis complicated with bilateral anterior circulation cerebral infarction

VernacularTitle:鼻眶脑型毛霉病继发双侧前循环脑梗死1例
Author: Yukun GUO ¹ ; Jin HOU ; Jian WANG ; Heng LI
Author Information

1. 山东大学齐鲁医学院，济南　250012
Keywords: Mucormycosis; Cerebral infarction; COVID-19; High-throughput nucleotide sequencing
From: Chinese Journal of Neurology 2024;57(1):70-74
CountryChina
Language:Chinese
Abstract: Rhino-orbito-cerebral mucormycosis (ROCM) is an acute, rapidly progressive, and lethal opportunistic fungal disease. Due to the atypical clinical manifestations, the disease is easily misdiagnosed in the early stage. The patients with ROCM associated cerebrovascular complications generally have a high mortality rate. This article reports a 47-year-old female patient with diabetic ketoacidosis and COVID-19 admitted to Central Hospital Affiliated to Shandong First Medical University. The results of radiological examinations and cerebrospinal fluid metagenomic next-generation sequencing confirmed as Rhizopus oryzae associated ROCM. In spite of receiving amphotericin B colloidal dispersion and isavuconazole treatments, the patient died of ROCM complicated with severe cerebral infarctions and pulmonary infection. The purpose of this case report is to summarize the clinical characteristics of ROCM with cerebrovascular ischemic events and the rare condition of bilateral anterior circulation involvements, and introduce recent diagnostic and therapeutic approaches for this disease.