Research progress of anti-inflammatory therapy for atherosclerosis
10.3760/cma.j.cn113694-20230301-00141
- VernacularTitle:动脉粥样硬化抗炎治疗的干预靶点探索
- Author:
Nan DONG
1
;
Xuan WU
;
Qi FANG
Author Information
1. 绍兴市中心医院神经内科，绍兴 312030
- Keywords:
Atherosclerosis;
Interleukin-1;
Interleukin-6;
C-reactive protein;
Anti-inflammatory therapy
- From:
Chinese Journal of Neurology
2023;56(11):1318-1324
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic inflammatory disease. In clinical practice, the main intervention target is to reduce low density lipoprotein cholesterol. Recent clinical data of several new lipid lowering drugs in the "post statin era" show that despite the use of high-intensity lipid lowering therapy, a large number of patients still have "residual inflammatory risk". In fact, in recent years, a large number of clinical studies have shown that anti-inflammatory treatment can effectively reduce the clinical complications of atherosclerosis, but it is also found that directly targeting/blocking inflammation may lead to increased immunosuppression or infection probability. Inflammation is a complex network involving the activation of multiple inflammatory cells, the release of inflammatory factors and the activation of inflammatory pathways. Therefore, it is necessary and significant to find effective and safe anti-inflammatory targets. Existing clinical evidence shows that targeting NOD-like receptor thermal protein domain associated protein 3/interleukin-1β/interleukin-6/hypersensitive-C-reactive protein pathway is an effective intervention target. In addition, targeted adaptive immunity, chemokines, and the release of proinflammatory regression mediators also show anti atherosclerosis effects. This article will summarize the latest progress in anti-inflammatory treatment of atherosclerosis in recent years, including the latest clinical research and the important progress still in the basic research stage, and look forward to the broad prospects of anti-inflammatory treatment of atherosclerosis.
