Effects of repetitive transcranial magnetic stimulation on synaptic plasticity in Alzheimer′s disease
10.3760/cma.j.cn113694-20230315-00198
- VernacularTitle:重复经颅磁刺激在改善阿尔茨海默病突触可塑性中的作用
- Author:
Yi JI
1
;
Xingqi WU
;
Kai WANG
Author Information
1. 安徽医科大学第一附属医院神经内科，合肥 230022
- Keywords:
Alzheimer disease;
Transcranial magnetic stimulation;
Cogniton;
Cortical excitability;
Synaptic plasticity
- From:
Chinese Journal of Neurology
2023;56(10):1195-1202
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease (AD), a progressive neurodegenerative disease, is characterized by dysfunction in execution and cognition, for which there are few efficient early interventions. Synaptic plasticity is regarded as a critical mechanism for learning and memory. Therefore, improving synaptic plasticity is correlated with promoting recovery after cognitive and motor impairment in patients with AD. Repetitive transcranial magnetic stimulation (rTMS) has been extensively utilized in AD rehabilitation for its potential to yield significant and enduring benefits in neural excitability and plasticity. This review overviews synaptic dysfunction in AD and primarily discusses the role of rTMS in alleviating clinical symptoms by influencing structural and functional plasticity of synapses, to explore its mechanisms for the treatment of neuropsychiatric disorders, and at the same time, provide clues and directions for further clinical translations.
