The value of skin detection in the diagnosis of synucleinopathies
10.3760/cma.j.cn113694-20230327-00223
- VernacularTitle:皮肤检测在突触核蛋白病诊断中的价值
- Author:
Yueying LIU
1
;
Kai LI
;
Wen SU
Author Information
1. 北京医院神经内科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730
- Keywords:
Skin;
Alpha-synuclein;
Synucleinopathies;
Real-time quaking-induced conversion;
Seeding activity
- From:
Chinese Journal of Neurology
2023;56(10):1189-1195
- CountryChina
- Language:Chinese
-
Abstract:
The prion-like propagation of α-synuclein (α-syn) is considered to be the key to the pathogenesis of synucleinopathies. A variety of α-syn detection methods have high sensitivity and specificity in the diagnosis of synucleinopathies. The detection of α-syn using skin samples is minimally invasive and less invasive, with high sensitivity and specificity, which has potential clinical application value in the diagnosis of synucleinopathies. In this paper, the latest development of α-syn detection in the diagnosis of synucleinopathies using skin samples is reviewed, emphasizing the clinical application of α-syn seeding activity in the early stage and differential diagnosis.
