Delayed diagnosis of autoimmune atrophic gastritis and its coping strategies
10.3760/cma.j.cn114798-20230403-00274
- VernacularTitle:自身免疫性萎缩性胃炎的诊断延误与应对策略
- Author:
Wuchang YAN
1
;
Jingrun ZHAO
Author Information
1. 山东第一医科大学附属聊城医院消化内科，聊城 252000
- Keywords:
Gastritis, atrophic;
Anemia, pernicious;
Anemia, iron-deficiency
- From:
Chinese Journal of General Practitioners
2023;22(10):1088-1092
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune atrophic gastritis (AAG) is a slowly progressive, immune‐mediated disorder with unspecific and subtle clinical manifestations. With the widespread use of endoscopy, especially the progression of early gastric cancer screening, it has increased awareness that AAG is a pre‐neoplastic condition, predisposing to the development of both type 1 neuroendocrine tumors and gastric adenocarcinoma. The diagnosis of AAG is based on distinctive endoscopic and histological features and serum intrinsic factor and/or parietal cell autoantibody positivity, which is challenging due to its wide clinical spectrum-ranging from a symptomless to a disabling disease course. This article summarizes the research progress of AAG in recent years, analyzes the reasons for delayed diagnosis of AAG, and proposes coping strategies.
