Structural and functional changes of the common carotid artery in patients with severe preeclampsia
10.3760/cma.j.cn114798-20230807-00047
- VernacularTitle:重度子痫前期患者颈总动脉结构和功能改变初探
- Author:
Wen ZHAO
1
;
Yuewei CAI
;
Jianping XU
Author Information
1. 山西省人民医院超声科，太原 030001
- Keywords:
Pre-eclampsia;
Carotid arteries;
Ultrasonography
- From:
Chinese Journal of General Practitioners
2023;22(10):1052-1056
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the structural and functional changes of the common carotid artery in patients with severe preeclampsia (SPE).Methods:Fifty-six patients with severe preeclampsia (SPE group) admitted in the First Hospital of Shanxi Medical University from May 2019 to December 2021, and 31 normal pregnant women admitted in the same period (control group) were enrolled in the study. All subjects underwent conventional ultrasonography and color Doppler sonography examinations. The QLAB software was used to measure intima-media thickness (IMT) and hemodynamics indexs, including systolic peak velocity (PSV), end diastolic velocity (EDV), vascular resistance index (RI) and vascular pulsation index (PI); the elastic parameters, including stiffness index β, the stress and strain modulus of elasticity Ep and compliance (AC). The clinical data and ultrasound parameters were compared between SPE group and control group. Logistic regression was used to analyze the correlation between elastic parameters and SPE.Results:Compared with the control group, the PSV, EDV were decreased, and RI was increased in the prenatal SPE group (all P<0.05). Compared with the control group, the Ep and stiffness index β increased in the SPE group, while AC decreased (all P<0.05). Multivariate logistic regression analysis showed that PSV ( OR=0.915, 95%CI: 0.859-0.974, P=0.005) was negatively correlated with SPE; IMT( OR=4.012, 95%CI:1.150-10.660, P=0.005), RI ( OR=9.279, 95%CI:1.781-46.743, P=0.013), Ep ( OR=1.086, 95%CI:1.031-1.142, P=0.002) were positively corrected with SPE. Conclusion:The structure and function of the common carotid artery have changed in patients with SPE.
