Long-term efficacy and literature review of liver transplant recipients with hepatic myelopathy
10.3760/cma.j.cn421203-20230206-00024
- VernacularTitle:肝性脊髓病肝移植后受者远期疗效观察并文献复习
- Author:
Zhaoxian LI
1
;
Yan XIE
;
Li ZHANG
;
Jisan SUN
;
Yanyan SUN
;
Xinghui YU
;
Zhongyang SHEN
;
Wentao JIANG
Author Information
1. 南开大学医学院，天津市第一中心医院肝移植科，天津市肝癌分子诊断与治疗重点实验室，天津 300192
- Keywords:
Liver transplantation;
Hepatic myelopathy;
Diseases of spinal cord;
Long-term effect
- From:
Chinese Journal of Organ Transplantation
2024;45(1):34-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the long-term therapeutic efficacy and outcomes of liver transplantation for patients with hepatic myelopathy (HM).Methods:Retrospective analysis of 24 adult liver transplantation recipients due to HM at First Central Municipal Hospital from January 2006 to October 2022. HM was extensively classified by the severity of lower extremity symptoms, degree of muscle stiffness, capability for independent ambulation and muscle strength. Furthermore, their long-term outcomes were examined. From January 2000 to October 2022, the databases of China National Knowledge Infrastructure (CNKI) , Google Scholar, PubMed and Web of Science were searched with such keywords as "肝性脊髓病and肝移植" "Hepatic Myelopathy and Liver Transplantation" .Results:After liver transplantation, liver functions and blood ammonia normalized and most clinical symptoms improved. During a follow-up period of (12-190) months, 19 patients showed a lowered grade of HC as compared to pre-transplantation. Four cases achieved a complete recovery of extremity function. No change occurred in severity grade for the remaining 5 patients. However, 4 of them experienced varying degrees of improvement in muscle strength and independent walking capability. This review summarized the clinical characteristics and clinical outcomes of 17 patients from both domestic and international sources. Most of them experiences varying degrees of symptomatic improvements after liver transplantation (16 cases).Conclusions:This study has confirmed the effectiveness of liver transplantation for HM and its contribution to the long-term patient recovery.
