Precision diagnosis and treatment of antibody-mediated rejection
10.3760/cma.j.cn421203-20231031-00148
- VernacularTitle:抗体介导排斥反应的精准诊疗
- Author:
Junchao CAI
1
;
Xin QING
;
Lei ZHANG
;
Lan ZHU
;
Longshan LIU
;
Puxun TIAN
;
Gang CHEN
Author Information
1. 苏州才博医学研究所，苏州 215009
- Keywords:
Donor specific antibody;
Antibody-mediated rejection;
Complement dependent cytotoxicity;
Complement dependent cellular cytotoxicity;
Complement dependent
- From:
Chinese Journal of Organ Transplantation
2024;45(1):1-17
- CountryChina
- Language:Chinese
-
Abstract:
Based upon the underlying mechanism and pathological evidence of tissue injury of antibody-mediated rejection (AMR) , four etiological and symptomatic therapies were proposed for managing AMR, including etiological treatment of AMR including antibody-targeting, B cell or plasma cell-targeting therapies; strategies for preventing antibody-mediated endothelial damage: an inhibition of complement/antibody dependent cell-mediated pathways; anticoagulant & thrombolytic therapies for thrombotic microangiopathy secondary to endothelial damage ; anti-inflammatory therapies for acute/chronic vascular inflammation secondary to endothelial damage. Etiological treatment is essential for preventing and treating AMR while symptomatic measures, such as anticoagulant, thrombolytic and antiinflammatory therapies, are stressed. Finally the authors devised therapeutic strategies for AMR in 4 different patient groups of non-sensitized allograft recipients, sensitized allograft recipients, individuals with active AMR and those with chronic active AMR.
