Diagnosis and treatment of severe SARS-CoV-2 infection after kidney transplantation: a report of 11 cases
10.3760/cma.j.cn421203-20230530-00117
- VernacularTitle:肾移植术后新型冠状病毒重症感染11例诊治报告
- Author:
Huijun CHEN
1
;
Jiazhao FU
;
Mingxing SUI
;
Hanlan LU
;
Wenyu ZHAO
;
Lei ZHANG
Author Information
1. 海军军医大学第一附属医院器官移植科，上海 200433
- Keywords:
Kidney transplantation;
COVID-19;
Immunosuppression
- From:
Chinese Journal of Organ Transplantation
2023;44(11):694-697
- CountryChina
- Language:Chinese
-
Abstract:
This review described the management of 11 recipients hospitalized with severe COVID-19 after kidney transplantation during the omicron variant epidemic in Shanghai from December 2022 to January 2023.After withdrawing oral immunosuppressants and starting immunoreplacement therapy, taking small molecule antiviral drugs and treating mixed infections, 10 recipients recovered and were discharged.One critically recipient died from a mixed bacterial and fungal infection after 80-day treatment.No overproduction of inflammatory cytokines was observed during treatment.And no rejection occurred during a cessation of oral immunosuppression.Delayed administration(>1 week of SARS-CoV-2 infection)of small molecule antiviral agents could effectively control viral replication.And there was simultaneous restoration of immune function.
