Advances of diagnosis and treatment solid organ transplantation associated progressive multifocal leukoencephalopathy
10.3760/cma.j.cn421203-20230522-00111
- VernacularTitle:实体器官移植相关进行性多灶性脑白质病诊治进展
- Author:
Peihang XU
1
;
Lulin WANG
;
Yuhang CAI
;
Qiaoyan LIAN
;
Xiaohua WANG
;
Xin XU
;
Jianxing HE
;
Chunrong JU
Author Information
1. 广州医科大学附属第一医院广州呼吸健康研究院，国家呼吸医学中心，国家呼吸疾病临床研究中心，呼吸疾病国家重点实验室，广州 510120
- Keywords:
Progressive multifocal leukoencephalopathy;
Organ transplantation;
Immunotherapy;
Central Nervous System Demyelination
- From:
Chinese Journal of Organ Transplantation
2023;44(9):568-573
- CountryChina
- Language:Chinese
-
Abstract:
Progressive multifocal leukoencephalopathy (PML) is a rare and yet serious central nervous system disorder due to JC viral infection.PML occurs predominantly in immunocompromised individuals, including solid organ transplant (SOT) recipients.Clinically, SOT-related PML commonly presents as cognitive and behavioral impairments. Pathologically, PML is characterized by multifocal demyelinating lesions, with neuroimaging technique typically revealing white matter damage in the temporoparietal regions. Clinical diagnosis usually involves integrating clinical manifestations, cranial magnetic resonance imaging, and detection of JC virus in cerebrospinal fluid. Currently, specific medications for PML are lacking, and the treatment mainly relies on supportive care and immunomodulatory strategies. The prognosis of PML remains unfavorable, early diagnosis and enhanced adaptive immune responses are crucial for PML management in SOT recipients.
