Review of interstitial fibrosis after ischemia reperfusion injury in transplanted kidney
10.3760/cma.j.cn421203-20221230-00341
- VernacularTitle:移植肾缺血再灌注损伤后间质纤维化
- Author:
Yi LIU
1
;
Heping NIU
;
Jiangwei MAN
;
Li YANG
Author Information
1. 兰州大学第二医院泌尿外科 兰州大学第二临床医学院，兰州 730030
- Keywords:
Kidney transplantation;
Ischemia-reperfusion injury;
Interstitial fibrosis and tubular atrophy;
Pericyte
- From:
Chinese Journal of Organ Transplantation
2023;44(8):508-512
- CountryChina
- Language:Chinese
-
Abstract:
The review focused upon the molecular mechanisms underlying ischemia reperfusion injury leading to interstitial fibrosis in transplanted kidneys, the roles of vascular dysfunction, epithelial cells, and pericytes in this process, the construction of different animal experimental models and their effects and recent novel approaches for the prevention and treatment of this process.
