Phenytoin sodium in the treatment of tacrolimus poisoning caused by paxlovid after kidney transplantation: a report of 2 cases
10.3760/cma.j.cn421203-20230220-00034
- VernacularTitle:苯妥英钠救治肾移植术后奈玛特韦/利托那韦致他克莫司中毒2例报道
- Author:
Xueyin XU
1
;
Qian FU
;
Chenglin WU
;
Huanxi ZHANG
;
Jun LI
;
Pan CHEN
;
Changxi WANG
Author Information
1. 中山大学药学院，广州 510006
- Keywords:
kidney transplantation;
tacrolimus;
phenytoin
- From:
Chinese Journal of Organ Transplantation
2023;44(8):496-498
- CountryChina
- Language:Chinese
-
Abstract:
This report describs 2 domestic cases of tacrolimus poisoning in kidney transplant recipients due to overexposure of tacrolimus caused by nirmatrelvir/ritonavir for SARS-CoV-2 infection.Phenytoin sodium is prescribed for inducing CYP3A enzyme.It is intended for providing references for formulating and adjusting treatment protocols for tacrolimus overexposure and related toxicity in kidney transplant recipients caused by nirmatrelvir/ritonavir.
