AngioJet-assisted catheter-directed thrombolysis versus catheter-directed thrombolysis alone in the treatment of acute deep venous thrombosis of lower extremity: a mid-term controlled clinical study
10.3760/cma.j.cn113855-20230620-00329
- VernacularTitle:Angiojet辅助导管接触性溶栓与单纯导管接触性溶栓治疗急性下肢深静脉血栓形成的中期临床对照研究
- Author:
Xinqing LI
1
;
Aimin QIAN
;
Chenglong LI
;
Xiaobin YU
;
Yeqing ZHANG
;
Fengrui LEI
;
Liwei ZHU
;
Zhixin CAI
;
Hongfei SANG
Author Information
1. 苏州大学附属第二医院血管外科，苏州 215000
- Keywords:
Venous thrombosis;
Post-thrombotic syndrome;
Angiojet rheolytic thrombectomy;
Catheter-directed thrombolysis
- From:
Chinese Journal of General Surgery
2024;39(2):110-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the mid-term clinical effects of AngioJet rheolytic thrombectomy assisted catheter-directed thrombolysis (ART+CDT) with catheter-directed thrombolysis (CDT) in the treatment of acute deep venous thrombosis of lower extremities.Methods:Ninety-one patients admitted to the Department from Jan 2016 to Dec 2017 were placed with inferior vena cava filters and divided into ART+CDT group (30 cases)and CDT group (61 cases). Total urokinase dosge, thrombolytic time, operative cost, length of hospital stay, detumescence rate, thrombus clearance rate, cumulative patency rate of lower limb veins, Villalta score at 2 years and 5 years, thrombosis recurrence rate and chronic venous insufficiency quality of life questionnaire were compared between the two groups.Results:The success rate of surgery was 100% in both groups, there was no mortality. There were significant differences in the short-term postoperative outcomes between the two groups in terms of total dosage of urokinase, thrombolysis time, total cost of surgery, length of hospital stay, detumescence rate, venous patency scores before and after treatment, and venous patency rate (all P<0.05). For the mid- and long-term postoperative outcomes of 2 and 5 years, there were no significant differences in the incidence of PTS, recurrence rate of thrombus, chronic venous function scale, and cumulative patency rate at 2 years (all P>0.05). Conclusions:ART+CDT has a significant advantage over CDT alone in terms of early efficacy and early reopening of blood flow in patients. Both ART+CDT and CDT have a low incidence of PTS and a low recurrence rate of thrombus in the mid-term follow-up, and both have satisfactory performance in the mid- and long-term efficacy of interventional treatment of deep venous thrombosis of lower limbs.
