Risk factors and prognosis of recurrence within 6 months after radical resection of intrahepatic cholangiocarcinoma
10.3760/cma.j.cn113855-20230617-00324
- VernacularTitle:肝内胆管癌根治性切除术后6个月内复发的危险因素及预后分析
- Author:
Zhenwei YANG
1
;
Pengyu CHEN
;
Hao YUAN
;
Zuochao QI
;
Guan HUANG
;
Haofeng ZHANG
;
Bo MENG
;
Xianzhou ZHANG
;
Haibo YU
Author Information
1. 河南大学人民医院（河南省人民医院）肝胆胰腺外科，郑州 450003
- Keywords:
Liver neoplasms;
Cholangiocarcinoma;
Prognosis;
Pathology, chinical characteristics;
Risk factors
- From:
Chinese Journal of General Surgery
2024;39(2):99-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relevant risk factors and prognosis of patients with intrahepatic cholangiocarcinoma (ICC) who experienced recurrence within 6 months after surgeryMethods:This retrospective study included a total of 259 patients with ICC a treated at He'nan Provincial People's Hospital and He'nan Cancer Hospital from Jan 2018 to Jan 2020. The clinical and pathological data ,differences between the group with recurrence within 6 months and the group without recurrence within 6 months were compared using the chi-square test. Logistic regression analysis was used to determine the relevant risk factors for recurrence within 6 months. Kaplan-Meier method was used to construct survival and recurrence curves, and survival rates were calculated.Results:The overall survival and recurrence-free survival of patients in the group with recurrence within 6 months were significantly shorter. CA19-9, tumor longitudinal diameter, microvascular invasion, and neural invasion were identified as independent risk factors for recurrence within 6 months after ICC surgery ( P<0.001). Conclusion:The patient population experiencing recurrence within 6 months after ICC surgery has an extremely poor prognosis and possesses a specific tumor microenvironment. CA19-9, tumor longitudinal diameter, microvascular invasion, and neural invasion were identified as independent risk factors for recurrence within 6 months after ICC surgery.
