Primary retroperitoneal soft tissue sarcoma resection combined with nephrectomy: a report 27 cases
10.3760/cma.j.cn113855-20221130-00745
- VernacularTitle:原发性腹膜后软组织肉瘤联合肾切除27例临床分析
- Author:
Jiaxin LIN
1
;
Dechang DIAO
;
Weilin LIAO
;
Jiahao WANG
;
Xin TANG
;
Wenjuan LI
;
Hongming LI
;
Xiaojiang YI
;
Xinquan LU
;
Xiaochuang FENG
;
Zhaoyu CHEN
Author Information
1. 广州中医药大学第二临床医学院，广州 510405
- Keywords:
Retroperitoneal neoplasms;
Nephrectomy;
Renal insufficiency;
Prognosis
- From:
Chinese Journal of General Surgery
2023;38(12):905-908
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of retroperitoneal soft tissue sarcoma resection combined with nephrectomy.Methods:The clinical data of 27 cases undergoing retroperitoneal soft tissue sarcoma resection combined with nephrectomy at the Gastrointestinal Tumor Center , Guangdong Provincial Hospital , Traditional Chinese Medicine from Jun 2017 to Aug 2022 were retrospectively analyzed for the indication of nephrectomy, postoperative progression of renal insufficiency and survival rate.Results:Twenty-six cases (96%) achieved R 0/R 1 resection and 1 case nderwent R 2 resection. Six cases underwent combined unilateral nephrectomy and 21 patients underwent combined multi-organ resection with a median number of resections of 4 (2,5). Postoperative pathology suggested that the combined resected kidney was positive for tumor infiltration in 17 cases. Five cases had Clavien-Dindo grade 3 or higher complications and no deaths occurred within 30 days after surgery. At the 90th day after surgery, 19 cases (70%) had decreased renal function ( Z=2.88, P=0.04), with a median decrease of -3.96 (-30.36, 0.31)ml·(min·1.73 m 2) -1, including 8 cases of preoperative Chronic Kidney Disease(CKD)1 stage progression (6 cases of CKD 2 stage, 2 cases of CKD 3 stage); 2 cases of CKD 2 stage progressed to CKD 3 stage; 1 case of preoperative CKD 3 stage progressed to CKD 4 stage. During the follow-up period of 3-38 months, no patient progressed to CKD 5 stage and no patient required dialysis treatment. Conclusion:Retroperitoneal soft tissue sarcoma resection combined with nephrectomy is safe and feasible while improving tumor radicality.
