A randomized controlled trial on sodium hyaluronate gel in prevention of postoperative intestinal adhesion
- VernacularTitle:透明质酸钠凝胶预防术后肠粘连的随机对照研究
- Author:
Wensheng HUANG
1
;
Jiancong HU
;
Chuanqing WU
;
Liang SHANG
;
Chengle ZHUANG
;
Ke AN
;
Zhichao ZHAI
;
Changmin DING
;
Zhaoya GAO
;
Qingkun GAO
;
Pengfei NIU
;
Yanzhao WANG
;
Qingmin ZENG
;
Yuming HONG
;
Wanshui RONG
;
Fuming LEI
;
Zhongchen LIU
;
Leping LI
;
Kaixiong TAO
;
Xiaojian WU
;
Jin GU
Author Information
- Keywords: Surgical procedures,operative; Abdomen; Adhension; Prevention
- From: Chinese Journal of General Surgery 2023;38(11):809-813
- CountryChina
- Language:Chinese
- Abstract: Objective:To evaluate the efficacy and safety of sodium hyaluronate gel in preventing adhesion after prophylactic enterostomy.Methods:One hundred and twenty four patients from 6 hospitals were enrolled in this prospective multi-center randomized controlled trial. Patients were randomized into the study group ( n=59) or the control group ( n=65).All patients underwent prophylactic enterostomy. Patients of study group received odium hyaluronate gel for adhesion-prevention,while those in control group did not receive any adhesion-prevention treatment. The incidence of moderate to severe adhesion around the incision in the stoma area were evalutated during stoma reduction surgery. Results:The incidence of moderate to severe adhesion around the incision in the stoma area was 6.3% in the study group, the difference was statistically significant ( P<0.05) compared to that of the control group (32.6%). Conclusion:Sodium hyaluronate gel can safely and effectively reduce the incidence of moderate and severe adhesions after abdominal surgery.
