The correlation between recurrent laryngeal nerve invasion and papillary thyroid carcinoma with posterior capsular involvment
10.3760/cma.j.cn113855-20220825-00527
- VernacularTitle:甲状腺乳头状癌侵犯后被膜与喉返神经受侵的相关因素分析
- Author:
Jialong WU
1
;
Changdong YANG
;
Debin JIN
;
Yan YANG
;
Boyang ZHANG
;
Peng QIN
;
Xue GENG
;
Zhongfeng MA
Author Information
1. 秦皇岛市第一医院头颈外科，秦皇岛 066000
- Keywords:
Thyroid neoplasms;
Recurrent laryngeal nerve;
Neoplasm invasiveness
- From:
Chinese Journal of General Surgery
2023;38(10):734-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the factors related to recurrent laryngeal nerve invasion in papillary thyroid carcinoma (PTC) with posterior capsular involvment.Methods:The data of 186 PTC patients admitted and operated from Jun 2017 to Jun 2022 were retrospectively analyzed. The invasion of recurrent laryngeal nerve was evaluated on its relation to gender, age, tumor size, Hashimoto's thyroiditis, lymph node metastasis in central region, BRAFV600E gene mutation especially PTC posterior capsular involvement.Results:The recurrent laryngeal nerve was invaded in 30 out of 186 patients. Univariate analysis showed that recurrent laryngeal nerve invasion was related to tumor size, Hashimoto's thyroiditis and cervical lymph node metastasis( χ2=6.964,4.814,6.078, P<0.05). Multivariate regression analysis showed that tumor size and lymph node metastasis in cervical region were independent risk factors for recurrent laryngeal nerve invasion(β=1.020,1.622, P<0.05). Hashimoto's thyroiditis was a protective factor for recurrent laryngeal nerve invasion (β=-1.881, P<0.05). Conclusions:When papillary thyroid carcinoma invaded the capsule, the risk of recurrent laryngeal nerve invasion was higher with larger tumor size and cervical lymph node metastasis, while Hashimoto's thyroiditis was a protective factor for the risk of recurrent nerve invasion.
