Postoperative calcitonin level as a predictor for recurrence of medullary thyroid carcinoma after resection
10.3760/cma.j.cn113855-20230818-00069
- VernacularTitle:术后血清降钙素水平对甲状腺髓样癌患者预后的预测价值
- Author:
Jingzhu ZHAO
1
;
Weijing HAO
;
Xianhui RUAN
;
Linfei HU
;
Jiadong CHI
;
Dapeng LI
;
Xiangqian ZHENG
Author Information
1. 天津医科大学肿瘤医院甲状腺颈部肿瘤科 国家恶性肿瘤临床医学研究中心 天津市 恶性肿瘤临床医学研究中心 天津市肿瘤防治重点实验室，天津 300060
- Keywords:
Thyroid neoplasms;
Calcitonin;
Lymphatic metastasis;
Prognosis
- From:
Chinese Journal of General Surgery
2023;38(10):729-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate postoperative calcitonin level as a prognostic marker in long-term follow-up of medullary thyroid carcinoma(MTC).Methods:Clinical data of 146 MTC cases treated at Tianjin Medical University Cancer Institute and Hospital from Jan 2011 to Dec 2019 were reviewed retrospectively. The relationship between postoperative calcitonin and disease-free survival was analyzed. According to the level of calcitonin six months after operation, patients were divided into normal level group and elevated group.Results:The median tumor size in those 146 cases was (1.78±1.22)cm, and 81 cases had lymph node metastasis. After 6 months of follow-up, 89 cases had normal calcitonin, with median tumor size of (1.63±1.20)cm, and 35 cases had lymph node metastasis . After a median follow-up of 56 months, 78 patients had normal calcitonin, 11 patients had biochemical relapse, 3 patients had structural relapse, and no patients died. 57 cases had a higher calcitonin ,median tumor size (1.97±1.22)cm, 46 cases had lymph node metastasis, 5 cases had distant metastasis, 18 cases had structural recurrence, and 7 patients died. Univariate analysis showed that lymph node metastasis, TNM stage, preoperative calcitonin, lymph node dissection and postoperative calcitonin were correlated with long-term disease-free survival (all P < 0.05). Multivariate analysis showed that postoperative calcitonin and TNM stage were an independent prognosis factor for disease-free survival in MTC patients (all P < 0.05). Conclusion:Postoperative calcitonin is a independent prognostic marker for long-term disease-free survival in MTC patients.
