Pathological characteristics and prognosis of 24 medullary thyroid carcinoma cases concomitant with papillary thyroid carcinoma
10.3760/cma.j.cn113855-20230821-00073
- VernacularTitle:甲状腺髓样癌合并乳头状癌24例的临床病理特征及预后分析
- Author:
Dapeng LI
1
;
Jinming ZHANG
;
Yanhui ZHANG
;
Linfei HU
;
Ying GAO
;
Songfeng WEI
;
Jie HAO
;
Xiangqian ZHENG
;
Ming GAO
Author Information
1. 天津医科大学肿瘤医院甲状腺颈部肿瘤科 国家恶性肿瘤临床医学研究中心 天津市恶性肿瘤临床医学研究中心 天津市肿瘤防治重点实验室，天津 300060
- Keywords:
Thyroid neoplasms;
Pathology, Clinical;
Prognosis
- From:
Chinese Journal of General Surgery
2023;38(10):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To analyze the clinical features and prognosis of patients with medullary thyroid carcinoma combined with papillary thyroid carcinoma (combined carcinoma).Methods:The clinical data of 24 patients admitted to Tianjin Medical University Cancer Hospital from Nov 2012 to Dec 2019 were retrospectively analyzed. The treatment methods, pathological results, and prognosis of all patients were examined.Results:The results showed that combined carcinoma accounted for 10.0% (24/241) of all medullary thyroid carcinoma cases. In the combined cancer group, 45.8% (11/24) patients had lymph node metastasis, and the type of metastasis matched the largest lesion. There were no significant differences in gendex ratio ( χ2=0.164, P>0.05), age at onset ( t=1.381, P>0.05), maximum diameter of lesion ( Z=-1.733, P>0.05), multifocality ( χ2=2.695, P>0.05), and lymph node metastasis in the central ( χ2=1.625, P>0.05) and lateral neck regions ( χ2=1.537, P>0.05) between combined cancer patients and those with MTC alone. The median follow-up time for the 24 patients was 77.6 months. Local recurrence was observed in 2 cases, while no distant metastasis was found. There were no significant differences in disease-free survival, disease-specific survival, and overall survival between combined cancer and pure MTC groups (all P>0.05). Conclusion:The pathological characteristics and prognosis of medullary thyroid carcinoma combined with papillary thyroid carcinoma are similar to those of pure MTC. Therefore, clinical treatment decisions can be similar to pure MTC.
