Role of systematic wound management in the treatment of Stevens-Johnson syndrome/toxic epidermal necrolysis in children
10.35541/cjd.20210881
- VernacularTitle:系统性创面管理在儿童Stevens-Johnson综合征/中毒性表皮坏死松解症治疗中的意义探讨
- Author:
Ying WANG
1
;
Lixin CHEN
;
Tiantian BI
;
Qinfeng LI
;
Jia LIAN
Author Information
1. 天津市儿童医院皮肤科，天津 300074
- Keywords:
Child;
Stevens-Johnson syndrome;
Wound management;
Treatment
- From:
Chinese Journal of Dermatology
2023;56(10):940-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of systematic wound management in the treatment of Stevens-Johnson syndrome (SJS) /toxic epidermal necrolysis (TEN) in children.Methods:Clinical data were collected from 5 children with SJS/TEN, who were admitted to the Department of Dermatology, Tianjin Children′s Hospital from October 2019 to August 2021, and retrospectively analyzed to investigate the role of systematic management of the skin and mucosa wound besides drug therapy in the treatment of SJS/TEN.Results:The 5 patients, including 1 case of SJS, 1 case of SJS/TEN overlap syndrome, and 3 cases of TEN, were aged 2 to 13 years, and were cured and discharged after the treatment with intravenous methylprednisolone and systematic wound management. Among the 5 children, the severity of TEN scores (STENS) were 18.6 ± 1.9 points at admission, and 13.8 ± 1.9, 4.4 ± 0.5, and 2.0 ± 0.7 points on days 7, 10, and 14 during hospitalization, respectively; the time to complete re-epithelialization was 10.0 ± 2.1 days, and the length of hospital stay was 14.4 ± 4.2 days. During 4-month multidisciplinary follow-up, no scars or complications of the eyes, mouth, genitalia, or lungs occurred.Conclusion:Systematic wound management is helpful to control the progress of SJS/TEN, accelerate wound healing, and improve patients′ quality of life.
