Insights into the progress in targeted therapy of atopic dermatitis from the perspective of its pathogenesis
- VernacularTitle:从特应性皮炎发病机制谈靶向治疗进展
- Author:
Zhiqiang SONG
1
;
Qiquan CHEN
;
Lan GE
Author Information
- Keywords: Dermatitis, atopic; Molecular targeted therapy; Biological agents; Janus kinases; Pathogenesis; Precision therapy
- From: Chinese Journal of Dermatology 2023;56(8):718-723
- CountryChina
- Language:Chinese
- Abstract: The pathogenesis of atopic dermatitis is complex, and mainly related to genetic background, environmental stimuli, epidermal barrier defects, immune disorders, and other factors. Using Th2-type inflammatory cytokines and the JAK-STAT pathway as therapeutic targets has become a hotspot in drug development for atopic dermatitis. By now, multiple monoclonal antibodies and small-molecule drugs have been successfully used in the treatment of atopic dermatitis, marking that the treatment of atopic dermatitis has entered the era of precision therapy and targeted therapy.
