Autoinflammatory dermatosis
- VernacularTitle:自身炎症性皮肤病
- Author:
Tao JIA
1
;
Xiangjin SONG
;
Songmei GENG
Author Information
- Keywords: Hereditary autoinflammatory diseases; Classification; Skin manifestations
- From: Chinese Journal of Dermatology 2023;56(8):794-799
- CountryChina
- Language:Chinese
- Abstract: Autoinflammatory diseases (AIDs) are a group of abnormal inflammatory diseases mediated by innate immune cells with a certain hereditary susceptibility, including monogenic AIDs and polygenic AIDs. AIDs are characterized by various clinical manifestations, periodic attacks and intermittent symptom relief, multiple systems are often involved, and skin is one of the predominantly involved organs. Due to genetic diversity and uncertainty in AIDs, gene-based classification is unhelpful in clinical recognitoin and selection of therapeutic strategies. With in-depth study on the pathogenesis of AIDs, researchers have found overlapping inflammatory pathways in AIDs sharing common skin lesions, which may be treated with similar strategies. This review describes classification of AIDs according to features of skin lesions, summarizes commonalities in their immune mechanisms and histopathological features, and discusses possible effective treatment regimens and interventions, in order to facilitate the clinical diagnosis and treatment.
