Clinical effects of Supplemented Buzhong Yiqi Decoction on patients with HP-positive chronic atrophic gastritis of Spleen-Stomach Deficiency Pattern
10.3969/j.issn.1001-1528.2024.02.019
- VernacularTitle:加味补中益气汤对脾胃虚弱型HP阳性慢性萎缩性胃炎患者的临床疗效
- Author:
Hui-Hu GAN
1
;
Lian-Ning JIN
;
Hong-Gen HUANG
;
Wen-Bo ZHOU
Author Information
1. 新余市中医院, 江西 新余 338025
- Keywords:
Buzhong Yiqi Decoction;
conventional treatment;
HP-positive chronic atrophic gastritis;
Spleen-Stomach Deficiency
- From:
Chinese Traditional Patent Medicine
2024;46(2):469-473
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Supplemented Buzhong Yiqi Decoction on patients with HP-positive chronic atrophic gastritis of Spleen-Stomach Deficiency Pattern.METHODS One hundred and thirty-two patients were randomly assigned into control group(66 cases)for 12-week intervention of conventional treatment,and observation group(66 cases)for 12-week intervention of both Supplemented Buzhong Yiqi Decoction and conventional treatment.The changes in clinical effects,HP clearance rate,miR-32,TGF-β1,IL-6,PGⅠ,PGⅡ,EGF,somatostatin,gastrin,motilin,gastroscopy pathological score and TCM symptom score were detected.RESULTS The observation group demonstrated higher total effective rate and HP clearance rate than the control group(P<0.05).After the treatment,the two groups displayed decreased miR-32,TGF-β1,IL-6,gastroscopy pathological score,TCM symptom score(P<0.05),and increased PGⅠ,PGⅡ,EGF,somatostatin,gastrin,motilin(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with HP-positive chronic atrophic gastritis of Spleen-Stomach Deficiency Pattern,Supplemented Buzhong Yiqi Decoction can alleviate inflammation,regulate gastrointestinal hormone levels,improve symptoms,and enhance efficacy.
