Optimization of processing technology and investigation of hematopoiesis activity of red Notoginseng Radix et Rhizoma
10.3969/j.issn.1001-1528.2024.01.009
- VernacularTitle:红三七炮制工艺优化及其补血活性研究
- Author:
Lang-Huan DUAN
1
;
Qi-Hui LI
;
Dong LÜ
;
Yong WANG
;
Xiu-Ming CUI
Author Information
1. 昆明理工大学生命科学与技术学院, 云南 昆明 650500
- Keywords:
red Notoginseng Radix et Rhizoma;
processing technology;
Box-Behnken response surface method;
fresh processing in the place of origin;
blood tonifying activity
- From:
Chinese Traditional Patent Medicine
2024;46(1):48-54
- CountryChina
- Language:Chinese
-
Abstract:
AIM To optimize the processing technology of red Notoginseng Radix et Rhizoma and evaluate its blood tonifying activity.METHODS On the basis of a single factor experiment,with steaming temperature,steaming time,drying temperature,and drying time as influencing factors,the total contents of notoginsenoside R1,ginsenoside Rg1,Rb1,Rk3,Rh4,and 20(R)-ginsenoside Rg3 as evaluation indicators,Box-Behnken response surface method ology was used to optimize the processing technology.Upon the anemic mouse models jointly induced by 1-acetyl-2-phenylhydrazine(APH)and cyclophosphamide(CTX),the investigation of the blood tonifying activity of red Notoginseng Radix et Rhizoma was carried out in contrast to that of the steamed Notoginseng Radix et Rhizoma.RESULTS The optimal conditions,contributing saponin content of 8.326%and RSD of 0.087%,were determined as follows:steaming temperature of 130℃,steaming time of 4 hours,drying temperature of 60℃,and drying time of 48 h.The pharmacological activity revealed that the different processing techniques were responsible for the different blood enriching activity of notoginseng,with red Notoginseng Radix et Rhizoma displaying a better efficacy than that of steamed Notoginseng Radix et Rhizoma.CONCLUSION This stable and feasible method can be used to control the production of red Notoginseng Radix et Rhizoma.
