Chemical constituents from Senecionis Scandentis Hebra and their protective effects on cardiomyocyte
10.3969/j.issn.1001-1528.2023.12.019
- VernacularTitle:千里光化学成分及其心肌细胞保护活性
- Author:
Ping LIU
1
;
Kai WU
;
Sheng-Wen ZHAO
Author Information
1. 海南省司法医院,海南 海口 571100
- Keywords:
Senecionis Scandentis Hebra;
chemical constituents;
isolation and identification;
protective effects on cardiomyocyte;
H9c2 cells
- From:
Chinese Traditional Patent Medicine
2023;45(12):3967-3971
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Senecionis Scandentis Hebra and their protective effects on cardiomyocyte.METHODS The 95%ethanol extract of S.scandens was isolated and purified by silica gel,Sephadex LH-20,MCI and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The protective effects of all compounds were tested on myocardial cells H9c2.RESULTS Seven compounds were isolated and identified as(R)-seneterniol(1),(1S,10S),(4S,5S)-germacrone-1(10),4-diepoxide(2),12-hydroxy-cyperone(3),urcumenone(4),isopterchiayione(5),curcumadione(6),gibberodione(7).The survival rates of H9c2 cells in compounds 2-3 and 5 were(75.2±0.54)%,(66.4±0.79)%,(59.7±0.91)%,respectively.CONCLUSION Compound 1 is a new compound.Compounds 2-7 are isolated from this plant for the first time.Compounds 2-3,5 have protective effects on cardiomyocyte.
