Clinical effects of Qushi Zhitong Pills on patients with rheumatoid arthritis
10.3969/j.issn.1001-1528.2023.12.015
- VernacularTitle:祛湿止痛丸对类风湿关节炎患者的临床疗效
- Author:
Xing-Fen ZHANG
1
;
Jun-Feng ZHANG
;
Ming-Wei CHEN
Author Information
1. 郑州市骨科医院,河南 郑州 450052
- Keywords:
Qushi Zhitong Pills;
conventional treatment;
rheumatoid arthritis
- From:
Chinese Traditional Patent Medicine
2023;45(12):3950-3953
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Qushi Zhitong Pills on patients with rheumatoid arthritis.METHODS Eighty-six patients were randomly assigned into control group(43 cases)for 3-month intervention of conventional treatment,and observation group(43 cases)for 3-month intervention of both Qushi Zhitong Pills and conventional treatment.The changes in clinical efficacy,DAS28 score,laboratory-related indices(ESR,RF,CRP),peripheral blood Th17,Treg,Th17/Treg,bone destruction-related indices(OPG,BGP,PⅠNP,RANKL)and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased DAS28 score,laboratory-related indices,Th17,Th17/Treg,PⅠNP,RANKL(P<0.05),and increased Treg,OPG,BGP(P<0.05),especially for the observation group(P<0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with rheumatoid arthritis,Qushi Zhitong Pills can regulate Th17/Treg balance,improve bone destruction,and increase bone mineral density.
