Association between remnant cholesterol levels and incident diabetic retinopathy in middle-aged and older patients with diabetes
10.3760/cma.j.cn112138-20230227-00116
- VernacularTitle:中老年糖尿病患者残余胆固醇与糖尿病视网膜病变发病风险的相关性研究
- Author:
Rong YU
1
;
Xuhong HOU
;
Xiangning WANG
;
Lili JIA
;
Xinhua DU
;
Qiang WU
;
Yuqian BAO
;
Weiping JIA
Author Information
1. 上海交通大学医学院附属第六人民医院内分泌代谢科 上海市糖尿病临床医学中心 上海市糖尿病重点实验室 上海市糖尿病研究所，上海 200233
- Keywords:
Diabetic retinopathy;
Cholesterol;
Dyslipidemias;
Prospective studies;
Remnant cholesterol
- From:
Chinese Journal of Internal Medicine
2023;62(12):1430-1435
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between remnant cholesterol (RC) and the risk of diabetic retinopathy (DR) in middle-aged and older individuals with diabetes.Methods:Based on the Shanghai Nicheng Cohort Study database, the data of 1 255 individuals with diabetes aged 55-70 years at baseline (2013-2014) with complete fundus photographs and serum cholesterol data in Nicheng, Shanghai, were analyzed. Multinomial logistic regression models were used to evaluate risk ratios ( RRs) and their 95% confidence intervals ( CIs) between baseline RC level and incident DR. Results:The median age of the subjects was 61.9 years, and 60.4% were women. After a 4.6-year follow-up, 79 (6.3%) patients developed DR, including 50 (4.0%) mild non-proliferative DR and 29 (2.3%) referable DR (RDR). Multivariable logistic regression showed that each mmol/L increase of RC was associated with a 40% higher risk of RDR ( RR=1.40, 95% CI 1.03-1.90). Compared with the lowest tertile of RC (<0.63 mmol/L), the risk of RDR in the highest tertile (≥0.85 mmol/L) increased by 4.59 times ( RR=5.59, 95% CI 1.51-20.73). Conclusion:The RC level may help identify individuals at high risk of incident RDR in middle-aged and older Chinese adults with diabetes.
