The 503rd case: monoclonal IgM immunoglobulinemia, severe anemia with recurrent fever
10.3760/cma.j.cn112138-20230302-00127
- VernacularTitle:第503例——单克隆IgM血症、重度贫血、反复发热
- Author:
Zhaoxuan ZHU
1
;
Qi WANG
;
Junling ZHUANG
;
Bing HAN
;
Miao CHEN
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院血液内科，北京 100730
- Keywords:
Waldenstrom macroglobulinemia;
Anemia, hemolytic, autoimmune;
Aplastic crisis;
Anemia of inflammation;
BTK inhibitor
- From:
Chinese Journal of Internal Medicine
2023;62(11):1369-1372
- CountryChina
- Language:Chinese
-
Abstract:
A 42-year-old woman was diagnosed with Waldenstr?m macroglobulinemia (WM) with fatigue, anemia, and monoclonal IgM immunoglobulinemia 6 years prior. She experienced persistent severe anemia with only transient remission after initial chemotherapy and after multiple chemotherapy regimens and immunosuppressive therapies, which were accompanied by recurrent high fever with severe complications including urinary infection, sepsis and shock, rectal perforation, and severe obstructive jaundice. The anemia was diagnosed as warm autoimmune hemolytic anemia and aplastic crisis with inflammation anemia. She received ibrutinib 140 mg once a day, and her hemoglobin levels returned to normal. WM remained stable in very good partial remission with no infection.
